We have discussed the issues with proxy server and Autodesk's online cloud services here.
There were few reported issues when "secureNAT" client is in use, these services don't work even with the work around mentioned in the link.
The issue is due to the ISA Firewall service performing reverse DNS name resolution to determine whether a rule applies for every request from SecureNAT client.
If you add Akamai hosts (*. edgekey.net & *.akamaiedge.net) to the exception lists this issue could be resolved.
Complete list of sites to have an exception rule on proxy for anonymous access would be.
*.autodesk.com
*.google-analytics.com
*.cloudfront.net
*. edgekey.net
*.akamaiedge.net
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